Publications | Dawson Research Lab

2023

Jamshidi N, Senthilvelan J, Dawson DW, Donahue TR, Kuo MD. (2023) Construction of a radiogenomic association map of pancreatic ductal adenocarcinoma. BMC Cancer 23(1):189. PMID: 36843111

2022

Mareninova OA, Dillon DL, Wightman CJM, Yakubov I, Takahashi T, Gaisano HY, Munson K, Ohmuraya M, Dawson D, Gukovsky I, Gukovskaya AS (2022) Rab9 mediates pancreatic autophagy switch from canonical to noncanonical, aggravating experimental pancreatitis Cell Mol Gastroenterol Hepatol. Cell Mol Gastroenterol Hepatol.13(2):599-622. PMID: 34610499
Abt ER, Le TM, Dann AM, Capri JR, Poddar S, Lok V, Li L, Liang K, Creech AL, Rashid K, Kim W, Wu N, Cui J, Cho A, Lee HR, Rosser EW, Link JM, Czernin J, Wu TT, Damoiseaux R, Dawson DW, Donahue TR, Radu CG. (2022) Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells. Cell Rep. 38(2):110236. PMID: 35021095.
Helms EJ, Berry MW, Chaw RC, DuFort CC, Sun D, Onate MK, Oon C, Bhattacharyya S, Sanford-Crane H, Horton W, Finan JM, Sattler A, Makar R, Dawson DW, Xia Z, Hingorani SR, Sherman MH. (2022) Mesenchymal Lineage Heterogeneity Underlies Nonredundant Functions of Pancreatic Cancer-Associated Fibroblasts. Cancer Discov. 12:484-501. PMID: 34548310
Aguilera KY, Le T, Riahi R, Lay AR, Hinz S, Saadat EA, Vashisht AA, Wohlschlegel J, Donahue TR, Radu CG, Dawson DW. (2022) Porcupine Inhibition Disrupts Mitochondrial Function and Homeostasis in WNT Ligand-Addicted Pancreatic Cancer. Mol Cancer Ther. 21(6):936-947. PMID: 35313331.
Kirtonia A, Pandey AK, Ramachandran B, Mishra DP, Dawson DW, Sethi G, Ganesan TS, Koeffler HP, Garg M. (2022) Overexpression of Laminin-5 Gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade. Cell Mol Life Sci. 79:362. PMID: 35699794
Pan S, Lai LA, Simeone DM, Dawson DW, Yan Y, Crnogorac-Jurcevic T, Chen R, Brentnall TA. (2022) Proteomes of Extracellular Vesicles from Pancreatic Cancer Cells and Cancer-Associated Fibroblasts. Pancreas 51:790-799. PMID: 36395405

2021

Aguilera KY, Dawson DW. (2021) WNT Ligand Dependencies in Pancreatic Cancer. Front Cell Dev Biol. 9:671022. doi: 10.3389/fcell.2021.671022. PMID: 33996827
Moore AM, Zhou L, Cui J, Li L, Wu N, Yu A, Possar S, Liang K, Abt ER, Kim S, Ghukasyan R, Khachatourian N, Pagano K, Elliot I, Dann AM, Riahi R, Le T, Dawson DW, Radu CG, Donahue TR. (2021) NAD+ depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition. Proc Nat Acad Sci. 118:e2012469118. PMID: 33597293
Gupta S, Yano J, Mercier V, Htwe HH, Shin HR, Rademaker G, Cakir Z, Ituarte T, Wen KW, Kim GE, Zoncu R, Roux A, Dawson DW, Perera RM. (2021) Lysosomal retargeting of Myoferlin mitigates membrane stress to enable pancreatic cancer growth. Nat Cell Biol. 23:232-242. PMID: 33686253
Mancinelli G, Torres C, Krett N, Bauer J, Castellanos K, McKinney R, Dawson D, Guzman G, Hwang R, Grimaldo S, Grippo P, Jung BH (2021) Role of stromal activin A in human pancreatic cancer and metastasis in mice. Sci Rep. 11(1):7986. doi: 10.1038/s41598-021-87213-y. PMID: 33846512
Mareninova OA, Vegh ET, Shalbueva N, Wightman CJ, Dillon DL, Malla S, Xie Y, Takahashi T, Rakonczay Z Jr, French SW, Gaisano HY, Gorelick FS, Pandol SJ, Bensinger SJ, Davidson NO, Dawson DW, Gukovsky I, Gukovskaya AS (2021) Dysregulation of mannose-6-phosphate-dependent cholesterol homeostasis in acinar cells mediates pancreatitis. J Clin Invest. 131(15):e146870. PMID: 34128834
Martin-Blais R, Pathak S, Fitzwater S, Dawson DW, Sisk AE, Farmer DG, Venick R, Yeganeh N. (2021) Intestinal mucormycosis initially identified by next-generation sequencing of cell-free DNA. Transpl Infect Dis. 23(4):e13656. PMID: 34176206
Pan S, Brand RE, Lai LA, Dawson DW, Donahue TR, Kim S, Khalaf NI, Othman MO, Fisher WE, Bronner MP, Simeone DM, Brentnall TA, Chen R. (2021) Proteome heterogeneity and malignancy detection in pancreatic cyst fluids. Clin Transl Med. 11(8):e506. dPMID: 34459141
Ferrian S, Liu CC, McCaffrey EF, Kumar R, Nowicki TS, Dawson DW, Baranski A, Glaspy JA, Ribas A, Bendall SC, Angelo M (2021) Multiplexed imaging reveals an IFN-γ-driven inflammatory state in nivolumab-associated gastritis. Cell Rep Med. 2(10):100419. PMID: 34755133
Mona CE, Benz MR, Hikmat F, Grogan TR, Lückerath K, Razmaria A, Riahi R, Slavik R, Girgis MD, Carlucci G, Kelly KA, French SW, Czernin J, Dawson DW*, Calais J (2021) Correlation of Ga-FAPi-46 PET biodistribution with FAP expression by immunohistochemistry in patients with solid cancers: a prospective translational exploratory study. J Nucl Med. doi: 10.2967/jnumed.121.262426. PMID: 34740953. *Co-senior author.

2020

Kim SS, Xu S, Cui J, Poddar S, Le TM, Hayrapetyan H, Li L, Wu N, Moore AM, Zhou L, Yu AC, Dann AM, Elliott IA, Abt ER, Kim W, Dawson DW, Radu CG, Donahue TR. (2020). Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression. Theranostics. 2020 Jan 1;10(2):829-840. doi: 10.7150/thno.40195. eCollection 2020. PMID:31903153
Current K, Meyer C, Magyar CE, Mona CE, Almajano J, Slavik R, Stuparu AD, Cheng C, Dawson DW, Radu CG, Czernin J, Lueckerath K. (2020) Investigating PSMA-targeted radioligand therapy efficacy as a function of cellular PSMA levels and intra-tumoral PSMA heterogeneity. Clin Cancer Res 26:2946-2955. PMID: 31932492
Kim SS, Xu S, Cui J, Poddar S, Le TM, Hayrapetyan H, Li L, Wu N, Moore AM, Zhou L, Yu AC, Dann AM, Elliott IA, Abt ER, Kim W, Dawson DW, Radu CG, Donahue TR. (2020) Histone deacetylase inhibition is synthetically lethal with arginine deprivation in pancreatic cancers with low argininosuccinate synthetase 1 expression. Theranostics 10(2):829-840. PMID: 31903153
Phan J, Dawson D, Sedarat A, Fejleh MP, Marya N, Thaker AM, Rogers M, Kim S, Muthusamy VR. (2020) Clinical Utility of Obtaining Endoscopic Ultrasound-Guided Fine-Needle Biopsies for Histologic Analyses of Pancreatic Cystic Lesions. Gastroenterology 158:475-477. PMID: 31738913
Wang H, Li X, Lai LA, Brentnall TA, Dawson DW, Kelly KA, Chen R, Pan S. (2020) X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma. Biochimie 181:25-33. PMID: 33242496
Park JY, King J, Reber H, Joe Hines O, Mederos MA, Wang HL, Dawson D, Wainberg Z, Donahue T, Girgis M. (2020) Poorly differentiated histologic grade correlates with worse survival in SMAD4 negative pancreatic adenocarcinoma patients. J Surg Oncol. 2020 Nov 4. doi: 10.1002/jso.26279. PMID: 33146409

2019

Koutsioumpa M, Hatziapostolou M, Polytarchou C, Tolosa EJ, Almada LL, Mahurkar-Joshi S, Williams J, Tirado-Rodriguez AB, Huerta-Yepez S, Karavias D, Kourea H, Poultsides GA, Struhl K, Dawson DW, Donahue TR, Fernández-Zapico ME, Iliopoulos D. (2019). Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming. Gut. 2019 Jul;68(7):1271-1286. doi: 10.1136/gutjnl-2017-315690. Epub 2018 Oct 18. PMID:30337373

2018

Sho S, Court CM, Winograd P, Toste PA, Pisegna JR, Lewis M, Donahue TR, Hines OJ, Reber HA, Dawson DW, Tomlinson JS. (2019). A Prognostic Scoring System for the Prediction of Metastatic Recurrence Following Curative Resection of Pancreatic Neuroendocrine Tumors. J Gastrointest Surg. 2019 Jul;23(7):1392-1400. doi: 10.1007/s11605-018-4011-7. Epub 2018 Oct 23. PMID:30353489
Principe DR, Overgaard NH, Park AJ, Diaz AM, Torres C, McKinney R, Dorman MJ, Castellanos K, Schwind R, Dawson DW, Rana A, Maker A, Munshi HG, Rund LA, Grippo PJ, Schook LB. (2018). KRASG12D and TP53R167H Cooperate to Induce Pancreatic Ductal Adenocarcinoma in Sus scrofa Pigs. Sci Rep. 2018 Aug 22;8(1):12548. doi: 10.1038/s41598-018-30916-6. PMID:30135483
Chang HH, Moro A, Chou CEN, Dawson DW, French S, Schmidt AI, Sinnett-Smith J, Hao F, Hines OJ, Eibl G, Rozengurt E. (2018). Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. Sci Rep. 2018 Apr 12;8(1):5899. doi: 10.1038/s41598-018-24337-8. PMID:29651002

2017

Schultz MA, Diaz AM, Smite S, Lay AR, DeCant B, McKinney R, Mascarinas WE, Xia Y, Neumann C, Bentrem D, Dawson DW, Grippo PJ. (2017). Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer. Oncotarget. 2017 Oct 4;8(54):92667-92681. doi: 10.18632/oncotarget.21539. eCollection 2017 Nov 3. PMID:29190947
Chang HH, Moro A, Takakura K, Su HY, Mo A, Nakanishi M, Waldron RT, French SW, Dawson DW, Hines OJ, Li G, Go VLW, Sinnett-Smith J, Pandol SJ, Lugea A, Gukovskaya AS, Duff MO, Rosenberg DW, Rozengurt E, Eibl G. (2017). Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice. PLoS One. 2017 Sep 8;12(9):e0184455. doi: 10.1371/journal.pone.0184455. eCollection 2017. PMID:28886117
Schludi B, Moin ASM, Montemurro C, Gurlo T, Matveyenko AV, Kirakossian D, Dawson DW, Dry SM, Butler PC, Butler AE. (2017). Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes. JCI Insight. 2017 Jul 6;2(13). pii: 92282. doi: 10.1172/jci.insight.92282. eCollection 2017 Jul 6. PMID:28679961
Liou GY, Bastea L, Fleming A, Döppler H, Edenfield BH, Dawson DW, Zhang L, Bardeesy N, Storz P. (2017). The Presence of Interleukin-13 at Pancreatic ADM/PanIN Lesions Alters Macrophage Populations and Mediates Pancreatic Tumorigenesis. Cell Rep. 2017 May 16;19(7):1322-1333. doi: 10.1016/j.celrep.2017.04.052. PMID:28514653
Sugimoto M, Hines OJ, Dawson DW, Muthusamy VR, Reber HA, Donahue TR. (2017). Preoperative Treatment With FOLFIRINOX and Successful Resection for a Patient With Mixed Acinar-Endocrine Carcinoma of the Pancreas. Pancreas. 2017 Apr;46(4):e32-e34. doi: 10.1097/MPA.0000000000000802. PMID:28291165
Schmidt A, Sinnett-Smith J, Young S, Chang HH, Hines OJ, Dawson DW, Rozengurt E, Eibl G. (2017). Direct growth-inhibitory effects of prostaglandin E2 in pancreatic cancer cells in vitro through an EP4/PKA-mediated mechanism. Surgery. 2017 Jun;161(6):1570-1578. doi: 10.1016/j.surg.2016.12.037. Epub 2017 Feb 20. PMID:28222855
Nguyen AH, Elliott IA, Wu N, Matsumura C, Vogelauer M, Attar N, Dann A, Ghukasyan R, Toste PA, Patel SG, Williams JL, Li L, Dawson DW, Radu C, Kurdistani SK, Donahue TR. (2017). Histone deacetylase inhibitors provoke a tumor supportive phenotype in pancreatic cancer associated fibroblasts. Oncotarget. 2017 Mar 21;8(12):19074-19088. doi: 10.18632/oncotarget.13572. PMID:27894105
Sugimoto M, Elliott IA, Nguyen AH, Kim S, Muthusamy VR, Watson R, Hines OJ, Dawson DW, Reber HA, Donahue TR. (2017). Assessment of a Revised Management Strategy for Patients With Intraductal Papillary Mucinous Neoplasms Involving the Main Pancreatic Duct. JAMA Surg. 2017 Jan 18;152(1):e163349. doi: 10.1001/jamasurg.2016.3349. Epub 2017 Jan 18. PMID:27829085
Williams JL, Chan CK, Toste PA, Elliott IA, Vasquez CR, Sunjaya DB, Swanson EA, Koo J, Hines OJ, Reber HA, Dawson DW, Donahue TR.(2017). Association of Histopathologic Phenotype of Periampullary Adenocarcinomas With Survival. JAMA Surg, Jan 1;152(1):82-88. doi: 10.1001/jamasurg.2016.3466. PMID:27732711

2016

Stark, A. P., Sacks, G. D., Rochefort, M. M., Donahue, T. R., Reber, H. A., Tomlinson, J. S., Dawson, D. W., Eibl, G., & Hines, O. J. (2016). Long-term survival in patients with pancreatic ductal adenocarcinoma. Surgery, 6,1520–1527. PMID:26847803
Principe, D. R., DeCant, B., MascariÃ±as, E., Wayne, E. A., Diaz, A. M., Akagi, N., Hwang, R., Pasche, B., Dawson, D. W., Fang, D., Bentrem, D. J., Munshi, H. G., Jung, B., & Grippo, P. J. (2016). TGFÎ² Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis. Cancer research, 9,2525–2539. PMID: 26980767
Toste, P. A., Nguyen, A. H., Kadera, B. E., Duong, M., Wu, N., Gawlas, I., Tran, L. M., Bikhchandani, M., Li, L., Patel, S. G., Dawson, D. W., & Donahue, T. R. (2016). Chemotherapy-Induced Inflammatory Gene Signature and Protumorigenic Phenotype in Pancreatic CAFs via Stress-Associated MAPK. Molecular cancer research : MCR, 5,437–447. PMID: 26979711
Moris, M., Dawson, D. W., Jiang, J., Lewis, J., Nassar, A., Takeuchi, K. K., Lay, A. R., Zhai, Q., Donahue, T. R., Kelly, K. A., Crawford, H. C., & Wallace, M. (2016). Plectin-1 as a Biomarker of Malignant Progression in Intraductal Papillary Mucinous Neoplasms: A Multicenter Study. Pancreas. PMID: 27101571
Hertzer, K. M., Xu, M., Moro, A., Dawson, D. W., Du, L., Li, G., Chang, H. H., Stark, A. P., Jung, X., Hines, O. J., & Eibl, G. (2016). Robust Early Inflammation of the Peripancreatic Visceral Adipose Tissue During Diet-Induced Obesity in the KrasG12D Model of Pancreatic Cancer. Pancreas, 3, 458–465. PMID: 26495779

2015

Arensman, M. D., Nguyen, P., Kershaw, K. M., Lay, A. R., Ostertag-Hill, C. A., Sherman, M. H., Downes, M., Liddle, C., Evans, R. M., & Dawson, D. W. (2015). Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer. Molecular cancer research : MCR, 11,1509–1519. PMID: 26224368
Mareninova, O. A., Sendler, M., Malla, S. R., Yakubov, I., French, S. W., Tokhtaeva, E., Vagin, O., Oorschot, V., LÃ¼llmann-Rauch, R., Blanz, J., Dawson, D., Klumperman, J., Lerch, M. M., Mayerle, J., Gukovsky, I., & Gukovskaya, A. S. (2015). Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis. Cellular and molecular gastroenterology and hepatology, 6,678–694. PMID: 26693174
Williams, J. L., Nguyen, A. H., Rochefort, M., Muthusamy, V. R., Wainberg, Z. A., Dawson, D. W., Tomlinson, J. S., Hines, O. J., Reber, H. A., & Donahue, T. R. (2015). Pancreatic cancer patients with lymph node involvement by direct tumor extension have similar survival to those with node-negative disease. Journal of surgical oncology, 4,396–402. PMID: 26303811
Toste, P. A., Li, L., Kadera, B. E., Nguyen, A. H., Tran, L. M., Wu, N., Madnick, D. L., Patel, S. G., Dawson, D. W., & Donahue, T. R. (2015). p85Î± is a microRNA target and affects chemosensitivity in pancreatic cancer. The Journal of surgical research, 2, 285–293. PMID: 25846727
Roy, N., Malik, S., Villanueva, K. E., Urano, A., Lu, X., Von Figura, G., Seeley, E. S., Dawson, D. W., Collisson, E. A., & Hebrok, M. (2015). Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation. Genes & development, 6, 658–671. PMID: 25792600

2014

Liou, G. Y., Döppler, H., Necela, B., Edenfield, B., Zhang, L., Dawson, D. W., & Storz, P. (2014). Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions. Cancer discovery, 1, 52–63. PMID: 25361845
Kadera, B. E., Toste, P. A., Wu, N., Li, L., Nguyen, A. H., Dawson, D. W., & Donahue, T. R. (2014). Low expression of the E3 ubiquitin ligase CBL confers chemoresistance in human pancreatic cancer and is targeted by epidermal growth factor receptor inhibition. Clinical cancer research : an official journal of the American Association for Cancer Research, 1, 157–165. PMID: 25348515
Chen, R., Dawson, D. W., Pan, S., Ottenhof, N. A., de Wilde, R. F., Wolfgang, C. L., May, D. H., Crispin, D. A., Lai, L. A., Lay, A. R., Waghray, M., Wang, S., McIntosh, M. W., Simeone, D. M., Maitra, A., & Brentnall, T. A. (2014). Proteins associated with pancreatic cancer survival in patients with resectable pancreatic ductal adenocarcinoma. Laboratory investigation; a journal of technical methods and pathology, 1, 43–55. PMID: 25347153
Thompson, M. J., Rubbi, L., Dawson, D. W., Donahue, T. R., & Pellegrini, M. (2015). Pancreatic cancer patient survival correlates with DNA methylation of pancreas development genes. PloS one, 6, PMID: 26039411
Nguyen, D., Dawson, D. W., Hines, O. J., Reber, H. A., & Donahue, T. R. (2014). Mucinous cystic neoplasms of the pancreas: are we overestimating malignant potential? The American surgeon, 10, 915–919. PMID: 25264629
Arensman, M. D., Telesca, D., Lay, A. R., Kershaw, K. M., Wu, N., Donahue, T. R., & Dawson, D. W. (2014). The CREB-binding protein inhibitor ICG-001 suppresses pancreatic cancer growth. Molecular cancer therapeutics, 10, 2303–2314. PMID: 25082960
Sherman, M. H., Yu, R. T., Engle, D. D., Ding, N., Atkins, A. R., Tiriac, H., Collisson, E. A., Connor, F., Van Dyke, T., Kozlov, S., Martin, P., Tseng, T. W., Dawson, D. W., Donahue, T. R., Masamune, A., Shimosegawa, T., Apte, M. V., Wilson, J. S., Ng, B., Lau, S. L., Gunton, J. E., Wahl, G. M., Hunter, T., Drebin, J. A., O'Dwyer, P. J., Liddle, C., Tuveson, D. A., Downes, M., & Evans, R. M. (2014). Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell, 1, 80–93. PMID: 25259922
von Figura, G., Fukuda, A., Roy, N., Liku, M. E., Morris Iv, J. P., Kim, G. E., Russ, H. A., Firpo, M. A., Mulvihill, S. J., Dawson, D. W., Ferrer, J., Mueller, W. F., Busch, A., Hertel, K. J., & Hebrok, M. (2014). The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nature cell biology, 3, 255–267. PMID: 24561622

2013

Arensman, M. D., Kovochich, A. N., Kulikauskas, R. M., Lay, A. R., Yang, P. T., Li, X., Donahue, T., Major, M. B., Moon, R. T., Chien, A. J., & Dawson, D. W. (2013). WNT7B mediates autocrine Wnt/Î²-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma. Oncogene, 7, 899–908. PMID: 23416978
Kadera, B. E., Sunjaya, D. B., Isacoff, W. H., Li, L., Hines, O. J., Tomlinson, J. S., Dawson, D. W., Rochefort, M. M., Donald, G. W., Clerkin, B. M., Reber, H. A., & Donahue, T. R. (2014). Locally advanced pancreatic cancer: association between prolonged preoperative treatment and lymph-node negativity and overall survival. JAMA surgery, 2, 145–153. PMID: 24306217
Toste, P. A., Kadera, B. E., Tatishchev, S. F., Dawson, D. W., Clerkin, B. M., Muthusamy, R., Watson, R., Tomlinson, J. S., Hines, O. J., Reber, H. A., & Donahue, T. R. (2013). Nonfunctional pancreatic neuroendocrine tumors Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 12, 2105–2113. PMID: 24101447
Dawson, D. W., Hertzer, K., Moro, A., Donald, G., Chang, H. H., Go, V. L., Pandol, S. J., Lugea, A., Gukovskaya, A. S., Li, G., Hines, O. J., Rozengurt, E., & Eibl, G. (2013). High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer prevention research (Philadelphia, Pa.), 10, 1064–1073. PMID: 23943783
Butler, A. E., Campbell-Thompson, M., Gurlo, T., Dawson, D. W., Atkinson, M., & Butler, P. C. (2013). Response to comments on: Butler et al. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013;62:2595-2604.Diabetes, 10,e19-22. PMID: 24065800
Farrell, J. J., Toste, P., Wu, N., Li, L., Wong, J., Malkhassian, D., Tran, L. M., Wu, X., Li, X., Dawson, D., Wu, H., & Donahue, T. R. (2013). Endoscopically acquired pancreatic cyst fluid microRNA 21 and 221 are associated with invasive cancer. The American journal of gastroenterology, 8, 1352–1359. PMID: 23752880
Liu, S. H., Zhou, G., Yu, J., Wu, J., Nemunaitis, J., Senzer, N., Dawson, D., Li, M., Fisher, W. E., & Brunicardi, F. C. (2013). Notch1 activation up-regulates pancreatic and duodenal homeobox-1. Genes, 3, 358–374. PMID: 24705209
Li, N., Wu, X., Holzer, R. G., Lee, J. H., Todoric, J., Park, E. J., Ogata, H., Gukovskaya, A. S., Gukovsky, I., Pizzo, D. P., VandenBerg, S., Tarin, D., Atay, C., Arkan, M. C., Deerinck, T. J., Moscat, J., Diaz-Meco, M., Dawson, D., Erkan, M., Kleeff, J., & Karin, M. (2013). Loss of acinar cell IKKÎ± triggers spontaneous pancreatitis in mice. The Journal of clinical investigation, 5, 2231–2243. PMID: 23563314
Kadera, B. E., Li, L., Toste, P. A., Wu, N., Adams, C., Dawson, D. W., & Donahue, T. R. (2013). MicroRNA-21 in pancreatic ductal adenocarcinoma tumor-associated fibroblasts promotes metastasis. PloS one, 8, PMID: 23991015

2012

Khachatoorian, R., Dawson, D., Maloney, E. M., Wang, J., French, B. A., French, S. W., & French, S. W. (2012). SAMe treatment prevents the ethanol-induced epigenetic alterations of genes in the Toll-like receptor pathway. Experimental and molecular pathology, 1,243–246. PMID: 23047067
Nguyen Kovochich, A., Arensman, M., Lay, A. R., Rao, N. P., Donahue, T., Li, X., French, S. W., & Dawson, D. W. (2012). HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma. Cancer, 3, 529–539. PMID: 22914903
Zhou, G., Liu, S. H., Shahi, K. M., Wang, H., Duan, X., Lin, X., Feng, X. H., Li, M., Fisher, W. E., Demayo, F. J., Dawson, D., & Brunicardi, F. C. (2012). Negative regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5. Molecular endocrinology (Baltimore, Md.), 7, 1225–1234. PMID: 22669743
Gier, B., Matveyenko, A. V., Kirakossian, D., Dawson, D., Dry, S. M., & Butler, P. C. (2012). Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model. Diabetes, 5, 1250–1262. PMID: 22266668
Mann, K. M., Ward, J. M., Yew, C. C., Kovochich, A., Dawson, D. W., Black, M. A., Brett, B. T., Sheetz, T. E., Dupuy, A. J., , ., Chang, D. K., Biankin, A. V., Waddell, N., Kassahn, K. S., Grimmond, S. M., Rust, A. G., Adams, D. J., Jenkins, N. A., & Copeland, N. G. (2012). Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America, 16, 5934–5941. PMID: 22421440
Donahue, T. R., Tran, L. M., Hill, R., Li, Y., Kovochich, A., Calvopina, J. H., Patel, S. G., Wu, N., Hindoyan, A., Farrell, J. J., Li, X., Dawson, D. W., & Wu, H. (2012). Integrative survival-based molecular profiling of human pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 5, 1352–1363. PMID: 22261810
Pandol, S., Gukovskaya, A., Edderkaoui, M., Edderkoui, M., Dawson, D., Eibl, G., & Lugea, A. (2012). Epidemiology, risk factors, and the promotion of pancreatic cancer: role of the stellate cell. Journal of gastroenterology and hepatology, , 127–134. PMID: 22320930
Camp, N. D., James, R. G., Dawson, D. W., Yan, F., Davison, J. M., Houck, S. A., Tang, X., Zheng, N., Major, M. B., & Moon, R. T. (2012). Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein. The Journal of biological chemistry, 9,6539–6550. PMID: 22215675
White, B. D., Chien, A. J., & Dawson, D. W. (2011). Dysregulation of Wnt/Î²-catenin signaling in gastrointestinal cancers. Gastroenterology, 2, 219–232. PMID: Label: 22155636
Biechele, T. L., Kulikauskas, R. M., Toroni, R. A., Lucero, O. M., Swift, R. D., James, R. G., Robin, N. C., Dawson, D. W., Moon, R. T., & Chien, A. J. (2012). Wnt/Î²-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. Science signaling, 206, PMID: 22234612
Gui, D., Cortina, G., Naini, B., Hart, S., Gerney, G., Dawson, D., & Dry, S. (2012). Diagnosis of dysplasia in upper gastro-intestinal tract biopsies through digital microscopy. Journal of pathology informatics, PMID: 23024886
Liu, S. H., Rao, D. D., Nemunaitis, J., Senzer, N., Zhou, G., Dawson, D., Gingras, M. C., Wang, Z., Gibbs, R., Norman, M., Templeton, N. S., Demayo, F. J., O'Malley, B., Sanchez, R., Fisher, W. E., & Brunicardi, F. C. (2012). PDX-1 is a therapeutic target for pancreatic cancer, insulinoma and islet neoplasia using a novel RNA interference platform. PloS one, 8, PMID: 22905092

2011

Zhou, G., Gingras, M. C., Liu, S. H., Sanchez, R., Edwards, D., Dawson, D., Christensen, K., Paganelli, G., Gibbs, R., Fisher, W., & Brunicardi, F. C. (2011). SSTR5 P335L monoclonal antibody differentiates pancreatic neuroendocrine neuroplasms with different SSTR5 genotypes. Surgery, 6, 1136–1142. PMID: 22136833
Donahue, T. R., & Dawson, D. W. (2011). Nodal/Activin signaling: a novel target for pancreatic cancer stem cell therapy. Cell stem cell, 5, 383–384. PMID: 22056131
Angst, E., Dawson, D. W., Stroka, D., Gloor, B., Park, J., Candinas, D., Reber, H. A., Hines, O. J., & Eibl, G. (2011). N-myc downstream regulated gene-1 expression correlates with reduced pancreatic cancer growth and increased apoptosis in vitro and in vivo. Surgery, 5, 614–624. PMID:21236457
Takahashi, H., Li, A., Dawson, D. W., Hines, O. J., Reber, H. A., & Eibl, G. (2011). Cyclooxygenase-2 confers growth advantage to syngeneic pancreatic cancer cells. Pancreas, 3, 453–459. PMID: 21356384
Li, A., King, J., Moro, A., Sugi, M. D., Dawson, D. W., Kaplan, J., Li, G., Lu, X., Strieter, R. M., Burdick, M., Go, V. L., Reber, H. A., Eibl, G., & Hines, O. J. (2011). Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer. The American journal of pathology, 3, 1340–1349. PMID: 21356384

2010

Hill, R., Calvopina, J. H., Kim, C., Wang, Y., Dawson, D. W., Donahue, T. R., Dry, S., & Wu, H. (2010). PTEN loss accelerates KrasG12D-induced pancreatic cancer development. Cancer research, 18, 7114–7124. PMID: 20807812
Lucero, O. M., Dawson, D. W., Moon, R. T., & Chien, A. J. (2010). A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers. Current oncology reports, 5, 314–318. PMID: 20603725
Angst, E., Dawson, D. W., Nguyen, A., Park, J., Go, V. L., Reber, H. A., Hines, O. J., & Eibl, G. (2010). Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells. Pancreas, 5,675–679. PMID: 20173668
Zhang, L., Angst, E., Park, J. L., Moro, A., Dawson, D. W., Reber, H. A., Eibl, G., Hines, O. J., Go, V. L., & Lu, Q. Y. (2010). Quercetin aglycone is bioavailable in murine pancreas and pancreatic xenografts. Journal of agricultural and food chemistry, 12, 7252–7257. PMID: 20499918
Pham, H., Chen, M., Li, A., King, J., Angst, E., Dawson, D. W., Park, J., Reber, H. A., Hines, O. J., & Eibl, G. (2010). Loss of 15-hydroxyprostaglandin dehydrogenase increases prostaglandin E2 in pancreatic tumors. Pancreas, 3,332–339. PMID: 19820419
Manuyakorn, A., Paulus, R., Farrell, J., Dawson, N. A., Tze, S., Cheung-Lau, G., Hines, O. J., Reber, H., Seligson, D. B., Horvath, S., Kurdistani, S. K., Guha, C., & Dawson, D. W. (2010). Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 8, 1358–1365. PMID: 20142597

2009

Balatoni, C. E., Dawson, D. W., Suh, J., Sherman, M. H., Sanders, G., Hong, J. S., Frank, M. J., Malone, C. S., Said, J. W., & Teitell, M. A. (2009). Epigenetic silencing of Stk39 in B-cell lymphoma inhibits apoptosis from genotoxic stress. The American journal of pathology, 4,1653–1661. PMID: 19717643
Chen, S. S., Raval, A., Johnson, A. J., Hertlein, E., Liu, T. H., Jin, V. X., Sherman, M. H., Liu, S. J., Dawson, D. W., Williams, K. E., Lanasa, M., Liyanarachchi, S., Lin, T. S., Marcucci, G., Pekarsky, Y., Davuluri, R., Croce, C. M., Guttridge, D. C., Teitell, M. A., Byrd, J. C., & Plass, C. (2009). Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America, 32, 13433–13438. PMID: 19666576
Frank, M. J., Dawson, D. W., Bensinger, S. J., Hong, J. S., Knosp, W. M., Xu, L., Balatoni, C. E., Allen, E. L., Shen, R. R., Bar-Sagi, D., Martin, G. R., & Teitell, M. A. (2009). Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas. Blood, 11,2478–2487. PMID:19147787

2008

Thomas, R. M., Kim, J., Revelo-Penafiel, M. P., Angel, R., Dawson, D. W., & Lowy, A. M. (2008). The chemokine receptor CXCR4 is expressed in pancreatic intraepithelial neoplasia. Gut, 11, 1555–1560. PMID: 18664506
Hasan, S., Satake, M., Dawson, D. W., Funahashi, H., Angst, E., Go, V. L., Reber, H. A., Hines, O. J., & Eibl, G. (2008). Expression analysis of the prostaglandin E2 production pathway in human pancreatic cancers. Pancreas, 2,121–127. PMID: 18665070
Tang, R. S., Weinberg, B., Dawson, D. W., Reber, H., Hines, O. J., Tomlinson, J. S., Chaudhari, V., Raman, S., & Farrell, J. J. (2008). Evaluation of the guidelines for management of pancreatic branch-duct intraductal papillary mucinous neoplasm. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 7, 815-9; quiz 719. PMID: 18602036

2007

Smiraglia, D. J., Kazhiyur-Mannar, R., Oakes, C. C., Wu, Y. Z., Liang, P., Ansari, T., Su, J., Rush, L. J., Smith, L. T., Yu, L., Liu, C., Dai, Z., Chen, S. S., Wang, S. H., Costello, J., Ioshikhes, I., Dawson, D. W., Hong, J. S., Teitell, M. A., Szafranek, A., Camoriano, M., Song, F., Elliott, R., Held, W., Trasler, J. M., Plass, C., & Wenger, R. (2007). Restriction landmark genomic scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations. BMC genomics. PMID: 18053125
Funahashi, H., Satake, M., Dawson, D., Huynh, N. A., Reber, H. A., Hines, O. J., & Eibl, G. (2007). Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor. Cancer research, 15, 7068–7071. PMID: 17652141
Dawson, D. W., Hong, J. S., Shen, R. R., French, S. W., Troke, J. J., Wu, Y. Z., Chen, S. S., Gui, D., Regelson, M., Marahrens, Y., Morse, H. C., Said, J., Plass, C., & Teitell, M. A. (2007). Global DNA methylation profiling reveals silencing of a secreted form of Epha7 in mouse and human germinal center B-cell lymphomas. Oncogene, 29, 4243–4252. PMID: 17260020
French, S. W., Dawson, D. W., Chen, H. W., Rainey, R. N., Sievers, S. A., Balatoni, C. E., Wong, L., Troke, J. J., Nguyen, M. T., Koehler, C. M., & Teitell, M. A. (2006). The TCL1 oncoprotein binds the RNase PH domains of the PNPase exoribonuclease without affecting its RNA degrading activity. Cancer letters, 2, 198–210. PMID: 16934922
Pelling, A. E., Dawson, D. W., Carreon, D. M., Christiansen, J. J., Shen, R. R., Teitell, M. A., & Gimzewski, J. K. (2007). Distinct contributions of microtubule subtypes to cell membrane shape and stability. Nanomedicine : nanotechnology, biology, and medicine, 1, 43–52. PMID:17379168

2006

Chen, H. W., Rainey, R. N., Balatoni, C. E., Dawson, D. W., Troke, J. J., Wasiak, S., Hong, J. S., McBride, H. M., Koehler, C. M., Teitell, M. A., & French, S. W. (2006). Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis. Molecular and cellular biology, 22, 8475–8487. PMID: 16966381

2005

Ouyang, Y., Salstrom, J., Diaz-Perez, S., Nahas, S., Matsuno, Y., Dawson, D., Teitell, M. A., Horvath, S., Riggs, A. D., Gatti, R. A., & Marahrens, Y. (2005). Inhibition of Atm and/or Atr disrupts gene silencing on the inactive X chromosome. Biochemical and biophysical research communications, 3, 875–880. PMID: 16213462
Hoyer, K. K., Herling, M., Bagrintseva, K., Dawson, D. W., French, S. W., Renard, M., Weinger, J. G., Jones, D., & Teitell, M. A. (2005). T cell leukemia-1 modulates TCR signal strength and IFN-gamma levels through phosphatidylinositol 3-kinase and protein kinase C pathway activation. Journal of immunology (Baltimore, Md. : 1950), 2, 864–873. PMID: 16002684

2003

Goodarzi, M. O., Dawson, D. W., Li, X., Lei, Z., Shintaku, P., Rao, C. V., & Van Herle, A. J. (2003). Virilization in bilateral macronodular adrenal hyperplasia controlled by luteinizing hormone. The Journal of clinical endocrinology and metabolism, 1, 73–77. PMID: 12519832

2002

French, S. W., Dawson, D. W., Miner, M. D., Doerr, J. R., Malone, C. S., Wall, R., & Teitell, M. A. (2002). DNA methylation profiling: a new tool for evaluating hematologic malignancies. Clinical immunology (Orlando, Fla.), 3 Pt 1, 217–230. PMID: 12173296

1999

Dawson, D. W., Volpert, O. V., Gillis, P., Crawford, S. E., Xu, H., Benedict, W., & Bouck, N. P. (1999). Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science (New York, N.Y.), 5425, 245–248. PMID: 10398599
Dawson, D. W., Volpert, O. V., Pearce, S. F., Schneider, A. J., Silverstein, R. L., Henkin, J., & Bouck, N. P. (1999). Three distinct D-amino acid substitutions confer potent antiangiogenic activity on an inactive peptide derived from a thrombospondin-1 type 1 repeat. Molecular pharmacology, 2, 332–338. PMID: 9927626

1997

Dawson, D. W., Pearce, S. F., Zhong, R., Silverstein, R. L., Frazier, W. A., & Bouck, N. P. (1997). CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. The Journal of cell biology, 3, 707–717. PMID: 9245797